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Shigeki Shibahara Selected Research

5-Aminolevulinate Synthetase

2/2014Identification of a novel erythroid-specific enhancer for the ALAS2 gene and its loss-of-function mutation which is associated with congenital sideroblastic anemia.
6/2012The carboxyl-terminal region of erythroid-specific 5-aminolevulinate synthase acts as an intrinsic modifier for its catalytic activity and protein stability.
3/2009Hypoxia induces erythroid-specific 5-aminolevulinate synthase expression in human erythroid cells through transforming growth factor-beta signaling.
6/2003Late-onset X-linked sideroblastic anemia following hemodialysis.

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Shigeki Shibahara Research Topics

Disease

17Hypoxia (Hypoxemia)
01/2010 - 08/2002
5Hepatocellular Carcinoma (Hepatoma)
01/2017 - 07/2006
5Neoplasms (Cancer)
12/2006 - 06/2002
4Neuroblastoma
10/2003 - 06/2002
3Melanoma (Melanoma, Malignant)
11/2014 - 01/2006
3Uterine Cervical Neoplasms (Cancer of the Cervix)
11/2008 - 07/2006
3Waardenburg syndrome type 2
03/2007 - 08/2002
3Glioblastoma (Glioblastoma Multiforme)
11/2006 - 08/2002
3Insulin Resistance
06/2006 - 02/2003
2Glioma (Gliomas)
01/2017 - 07/2003
2Cholangiocarcinoma
01/2017 - 01/2016
2Liver Neoplasms (Liver Cancer)
01/2017 - 01/2016
2Hypertension (High Blood Pressure)
12/2016 - 05/2007
2Sideroblastic Anemia
02/2014 - 06/2003
2X-linked sideroblastic anemia
06/2012 - 06/2003
2Acute Erythroblastic Leukemia (Erythroleukemia)
03/2009 - 07/2006
2Obesity
12/2008 - 05/2007
2Metabolic Syndrome (Dysmetabolic Syndrome X)
05/2007 - 06/2006
2Hypopigmentation (Hypomelanosis)
06/2003 - 08/2002
2Deafness (Deaf Mutism)
06/2003 - 08/2002
2Proliferative Vitreoretinopathy
04/2003 - 10/2002
2Ganglioneuroblastoma
02/2003 - 06/2002
2Renal Cell Carcinoma (Grawitz Tumor)
02/2003 - 08/2002
2Adrenocortical Carcinoma
02/2003 - 08/2002
2Pheochromocytoma
02/2003 - 06/2002
1Iron Overload
12/2016
1Nervous System Diseases (Neurological Disorders)
12/2016
1Metrorrhagia (Spotting)
01/2016
1Hearing Loss (Hearing Impairment)
11/2014
1Deaf-Blind Disorders
11/2014
1Macular Degeneration (Age-Related Maculopathy)
11/2014
1Megacolon
10/2006
1Hirschsprung Disease (Hirschsprung's Disease)
04/2006
1Cerebral Malaria
10/2005
1Microphthalmos
06/2005
1Adenocarcinoma of Lung
04/2005
1Hypercapnia
07/2004

Drug/Important Bio-Agent (IBA)

15Messenger RNA (mRNA)IBA
01/2016 - 06/2002
12Proteins (Proteins, Gene)FDA Link
01/2016 - 07/2004
10Heme (Haem)IBA
02/2014 - 03/2003
8Heme Oxygenase-1IBA
01/2010 - 01/2003
5heme oxygenase-2IBA
01/2010 - 07/2004
5Oxygen (Dioxygen)IBA
12/2007 - 03/2003
5AdrenomedullinIBA
06/2006 - 10/2002
5Peptides (Polypeptides)IBA
06/2006 - 06/2002
4EnzymesIBA
02/2014 - 08/2003
45-Aminolevulinate SynthetaseIBA
02/2014 - 06/2003
4CytokinesIBA
03/2008 - 04/2003
3Retinal Pigments (Pigments, Visual)IBA
11/2008 - 04/2003
3Vasodilator Agents (Vasodilators)IBA
05/2007 - 09/2003
3Microphthalmia-Associated Transcription FactorIBA
03/2007 - 08/2002
3Endothelin-1 (Endothelin 1)IBA
11/2006 - 08/2002
3Interferon-gamma (Interferon, gamma)IBA
11/2006 - 08/2002
3Endothelin Receptors (Endothelin Receptor)IBA
10/2006 - 08/2002
3Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA
07/2006 - 01/2003
2IronIBA
12/2016 - 03/2009
2CadmiumIBA
11/2014 - 12/2008
2Hemoglobins (Hemoglobin)IBA
06/2012 - 03/2009
2ErythropoietinFDA Link
03/2009 - 03/2003
2AntioxidantsIBA
12/2008 - 05/2007
2OxygenasesIBA
12/2007 - 12/2005
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2006 - 09/2003
2ResistinIBA
09/2003 - 02/2003
2GlucocorticoidsIBA
07/2003 - 04/2003
2RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
02/2003 - 06/2002
1carbazoleIBA
01/2017
1Transcription Factors (Transcription Factor)IBA
01/2017
1mahanineIBA
01/2017
1AlkaloidsIBA
01/2017
1tetrahydrocurcuminIBA
12/2016
1DNA Transposable Elements (Element, IS)IBA
12/2016
1Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
12/2016
1Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2016
1Saccharated Ferric Oxide (Venofer)FDA Link
12/2016
1DeferiproneIBA
12/2016
1cyclopamineIBA
01/2016
1beta CateninIBA
01/2016
1Cyclin D1IBA
01/2016
1Glucose (Dextrose)FDA LinkGeneric
01/2012
1Prostaglandins DIBA
08/2010
1LipocalinsIBA
07/2009
1prostaglandin R2 D-isomerase (prostaglandin D2 synthase)IBA
07/2009
1Transforming Growth Factor beta (TGF-beta)IBA
03/2009
1Hypoxia-Inducible Factor 1IBA
03/2009
1gamma-GlobinsIBA
03/2009
1DNA (Deoxyribonucleic Acid)IBA
03/2009
1Transforming Growth Factors (Transforming Growth Factor)IBA
03/2009
1Transforming Growth Factor beta1 (TGF beta 1)IBA
03/2009
1cobaltous chloride (cobalt(II)chloride)IBA
12/2008
1MetalsIBA
12/2008
1Deferoxamine (Desferal)FDA LinkGeneric
12/2008
1TetrapyrrolesIBA
12/2008
1Prolyl-Hydroxylase InhibitorsIBA
11/2008
1ethyl protocatechuateIBA
11/2008
1Interleukin-1beta (Interleukin 1 beta)IBA
11/2006
1Endothelins (Endothelin)IBA
11/2006
1SOXE Transcription FactorsIBA
10/2006
1Endothelin-3 (Endothelin 3)IBA
04/2006
1Monophenol Monooxygenase (Tyrosinase)IBA
10/2003

Therapy/Procedure

1Traditional Medicine (Folk Remedies)
01/2017